P. IVA 05658320725
Curriculum:
Nato a Münster (Germania), cittadinanza tedesca
Sposato, due figlie (Delia e Laura)
Membro della European Academy of Neurology
Membro della Deutsche Gesellschaft für Neurologie (Società Tedesca di Neurologia)
1984 Laurea in Medicina e Chirurgia presso l’Università di Bologna (110/110 con lode)
1986-89 Istituto di Neuropatologia dell’Università di Düsseldorf
1989-91 Centro di Biologia molecolare dell’Università di Heidelberg
1992-99 Neurologo al dipartimento di Neurologia dell’Università di Düsseldorf
1995-99 Neurologo consulente ai dipartimenti di Psichiatria, Medicina Interna, Cardiologia, Reumatologia, Ematologia e Rianimazione dell’Università di Düsseldorf
2000 Libera Docenza (Privat-Dozent) in Neurologia conferita dalla facoltà di Medicina dell’Università di Düsseldorf
1993-2000 Group leader del gruppo di ricerca molecolare sul morbo di Alzheimer dell’Università di Düsseldorf
All’università di Heidelberg svolgimento per due anni di un proprio corso di lezioni in Neuropatologia molecolare nell'ambito del corso di laurea in Biologia
All’università di Düsseldorf attività didattica regolare nei corsi di Neurologia clinica, Psichiatria clinica e durante l’esercizio di pratica clinica nell'ambito del corso di laurea in Medicina e Chirurgia
Nel 1999 premio scientifico ricevuto a Berlino da parte della "Hirnliga" (Lega per le malattie cerebrali) per i lavori di ricerca sul morbo di Alzheimer e una pubblicazione su Nature Medicine
Dal 2001 al 2017 Medical coordinator per "Health Information Management" a Bruxelles
Dal 2004 al 2008 Neurologo consulente dei dipartimenti di cardiologia, cardiochirurgia e terapia intensiva dell' Anthea Hospital a Bari
Dal 2010 al 2012 Coordinatore scientifico di due grandi trial clinici multicentrici sponsorizzati dalla Comunitò Europea ( DREAMING, RENEWING HEALTH)
Dal 2012 al 2013 Medical Advisor (sviluppo farmacologico, ricerca clinica, valutazione di effetti collaterali dei farmaci) per Eli Lilly in Germania
Dal 2013 al 2015 Neurologo al centro neurologico e radiologico a Heidelberg (Mosbach, Germania)
Dal 2014 al 2017 Coordinatore scientifico di un progetto della Comunità Europea sulla terapia della depressione tramite Internet (MasterMind)
Dal 2015 al 2016 Medical Consultant per Biogen Germania
Dal 2017 Principal Clinician in studi clinici in pazienti con Parkinson e Alzheimer per Medavante (USA)
Dal 2021 Dirigente Medico ASL Bari Sud nell'ambito della campagna vaccinale Covid19
Dal 2021 Scientific Consultant per Ceregate (Sviluppo di algoritmi avanzati per la stimolazione cerebrale profonda nella malattia di Parkinson)
Pubblicazioni scientifiche
(Sono riportate solo le pubblicazioni originali e le pubblicazioni su riviste internazionali con 'Peer-review', non sono riportate le numerose partecipazioni a conferenze e congressi con relazioni o poster)
Prior R: Legame dei farmaci alle proteine plasmatiche in gravidanza: studio sull'acido valproico (University of Bologna, Italy, MD thesis, 1984)
Prior R: Immunhistochemische Untersuchungen zur Expression neuroendokriner Marker in menschlichen Hypophysenadenomen (University of Düsseldorf, Germany, MD thesis, 1990)
Van Valen F, Prior R, Wechsler W, Jürgens H, Keck E: An immunocytochemical and biochemical study of Ewing's sarcoma cells in culture: evidence for neural differentiation in vitro. In: Heuck FHW, Keck E (eds): Osteologia 3, Springer Verlag, Berlin Heidelberg New York London Paris Tokyo, pp 341-348 (1988)
Van Valen F, Prior R, Wechsler W, Jürgens H, Schäfer U, Keck E: Immunzytochemische und biochemische Untersuchungen an einer Ewing-Sarkom Zellinie: Hinweise für eine neurale in-vitro Differenzierung. Klin Pädiatr 200: 267-270 (1988)
Grabitz K, Freye E, Prior R, Braun M: Protection from spinal cord injury by intravenous prostaglandin E1 (PGE1) after one hour occlusion of the descending thoracic aorta. In: Prostaglandins in Clinical Research: Cardiovascular System, Alan R. Liss, Inc., New York pp 211-216 (1989)
Reifenberger G, Prior R, Deckert M, Wechsler W: Epidermal growth factor receptor expression and growth fraction in human tumours of the nervous system. Virchows Archiv A Pathol Anat 414: 147-155 (1989)
Prior R, Reifenberger G, Wechsler W: Nerve growth factor receptor in tumours of the human nervous system. Immunohistochemical analysis of receptor expression and tumour growth fraction. Pathol Res Practice 185: 332-338 (1989)
Grabitz K, Freye E, Prior R: Die Wirkung von Prostaglandin E1 und Superoxid-Dismutase auf die Ischämietoleranzzeit des Rückenmarkes. Eine tierexperimentelle Studie mit evozierten Potentialen. Z Herz Thorax Gefäßchir 4: 31-37 (1990)
Prior R, Reifenberger G, Wechsler W: Transferrin receptor expression and growth fraction in tumours of the human nervous system. Virchows Archiv A Pathol Anat 416: 491-496 (1990)
Clahsen H, Lipfert P, Prior R, Hahner J: Die Bindungsfähigkeit des Perineuriums für PNA-Lektin während der Waller'schen Degeneration. Verh Anat Ges 83:549-550 (1990)
Grabitz K, Freye E, Prior R, Sandmann W: Does Prostaglandin E1 and Superoxide Dismutase prevent ischemic spinal cord injury after thoracic aortic cross-clamping? Eur J Vasc Surg 4: 19-24 (1990)
Catteruccia N, Willingale-Theune J, Bunke D, Prior R, Masters CL, Crisanti A, Beyreuther K: Ultrastructural localization of the putative precursors of the A4 amyloid protein associated with Alzheimer's disease. Am J Pathol 137: 19-26 (1990)
Grabitz K, Freye E, Prior R, Kolvenbach R, Sandmann W: The role of superoxide dismutase (SOD) in preventing postischemic spinal cord injury. In: Emerit I, Packer L, Auclair C (eds): Antioxidants in Therapy and Preventive Medicine, Plenum Press, New York, 13-16 (1990)
Schrell UMH, Adams EF, Fahlbusch R, Greb R, Jirikowski G, Prior R, Ramalho-Ortigao FJ: Hormonal dependency of cerebral meningiomas. Part I: female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. J Neurosurg 73: 743-749 (1990)
Mönning U, König G, Prior R, Mechler H, Schreiter-Gasser U, Masters CL, Beyreuther K: Synthesis and secretion of Alzheimer amyloid ßA4 precursor protein by stimulated human peripheral blood leucocytes. FEBS Letters 277: 261-266 (1990)
Mönning U, Schreiter-Gasser U, Hilbich C, Bunke D, Prior R, Masters CL, Beyreuther K: Alzheimer Amyloid ßA4-protein reactive antibodies in human sera and CSF. In: Alzheimer's disease: basic mechanisms, diagnosis and therapeutic strategies, Wiley, Chichester, pp 557-562 (1991)
Prior R, Mönning U, Weidemann A, Fischer P, Blennow K, Gottfries CG, Masters CL, Beyreuther K: ELISA quantitation of the amyloid A4 precursor protein in cerebrospinal fluid. In: Alzheimer's disease: basic mechanisms, diagnosis and therapeutic strategies, Wiley, Chichester, pp 533-540 (1991)
Prior R, Mönning U, Schreiter-Gasser U, Weidemann A, Blennow K, Gottfries CG, Masters CL, Beyreuther K: Quantitative changes of the amyloid A4 precursor protein in Alzheimer's disease cerebrospinal fluid. Neurosci Letters 124: 69-73 (1991)
Schubert W, Prior R, Weidemann A, Dircksen H, Multhaup G, Masters CL, Beyreuther K: Localization of Alzheimer ßA4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res 563: 184-194 (1991)
Prior R, Masters CL, Beyreuther K: Molekulare Pathogenese der Alzheimerschen Krankheit. Chemie in Labor und Biotechnik 42: 483-486 (1991)
Beyreuther K, Bush AI, Dyrks T, Hilbich C, König G, Mönning U, Multhaup G, Prior R, Rumble B, Schubert W, Weidemann A, Masters CL: Mechanisms of amyloid deposition in Alzheimer´s disease. Ann N Y Acad Sci 640: 129-139 (1991)
Beyreuther K, Multhaup G, Prior R, Masters CL: Neurobiologie der Alzheimerschen Krankheit. In: Häfner H, Hennerici M (eds): Aktuelle Psychiatrie, Vol. 8, Gustav Fischer Stuttgart Jena New York (1992), pp 61-78
Prior R, Mönning U, Masters CL, Beyreuther K: Unravelling the molecular defect in Alzheimer's disease. In: Zwilling R, Baldini L (eds) Biology of aging, Springer Verlag Berlin Heidelberg: 72-81 (1992)
Prior R, Schober R, Wechsler W: Microocclusive angiopathy by immunoglobulin (IgM-kappa) precipitation - pathogenetic relevance in paraneoplastic cryoglobulinemic neuropathy. Acta Neuropathol 83: 423-426 (1992)
König G, Mönning U, Czech C, Prior R, Banati R, Schreiter-Gasser U, Bauer J, Masters CL, Beyreuther K: Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leucocytes and brain microglial cells. J Biol Chem 267: 10804-10809 (1992)
Weidemann A, Prior R, Masters CL, Beyreuther K: Cytoplasmic isoforms of the amyloid precursor protein result from alternative initiation of translation. In: Corain B, Iqbal K, Nicolini M, Winblad B, Wisniewski HM, Zatta PF (eds) Alzheimer's disease: advances in clinical and basic research, Wiley and Sons Chichester New York Brisbane Toronto Singapore (1993), pp 405-410
Prior R, D'Urso D, Frank R, Prikulis I, Pavlakovic G: Experimental deposition of Alzheimer amyloid ß-protein in canine leptomeningeal vessels. Neuroreport 6: 1747-1751 (1995)
Prior R, D'Urso D, Frank R, Prikulis I, Pavlakovic G: Loss of vessel wall viability in cerebral amyloid angiopathy. Neuroreport 7: 562-564 (1996)
Prior R, D'Urso D, Frank R, Prikulis I, Cleven S, Ihl R, Pavlakovic G: Selective binding of soluble Aß1-40 and Aß1-42 to a subset of senile plaques. Am J Pathol 148: 1749-1756 (1996)
Prior R, D'Urso D, Prikulis I, Wihl G, Pavlakovic G: Canine leptomeningeal organ culture: a new experimental model for cerebrovascular ß-amyloidosis. J Neurosci Meth 68: 143-148 (1996)
Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, St. George Hyslop P, Selkoe DJ, Haass C: The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine 2: 673-691 (1996
D'Urso D, Schmalenbach C, Zoidl G, Prior R, Müller HW: Studies on the effects of altered PMP22 expression during myelination in vitro. J Neurosci Res 48: 31-42 (1996)
Urmoneit B, Prikulis I, Wihl G, D'Urso D, Frank R, Heeren J, Beisiegel U, Prior R: Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a lipoprotein pathway - implications for cerebral amyloid angiopathy. Lab Invest 77:157-166 (1997)
D'Urso D, Prior R, Greiner-Petter R, Gabreels-Festen AAWM, Muller HW: Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22. J Neurosci 18:731-740 (1998)
Prior R: Die Amyloid-Angiopathie der Alzheimer-Krankheit (Tesi per la docenza in neurologia)
Pitschke M, Prior R, Haupt M, Riesner D: Detection of single amyloid ß-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nature Med 4: 832-834 (1998)
Prior R, Urmoneit B: Amyloid ß protein internalization and production by canine smooth muscle cells. In: Verbeek MM, de Waal RMW, Vinters HV (eds): Cerebrovascular amyloidosis (CAA) in Alzheimer’s disease and related disorders. Kluwer Academic Publishers Dordrecht Boston London, pp 251-264 (2000)
Prior R, Wihl G, Urmoneit B: Apolipoprotein E: Smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy. Ann N Y Acad Sci 903:180-186 (2000)
Dallolio L, Menarini M, China S, Ventura M, Stainthorpe A, Soopramanien A, Rucci P, Fantini MP; THRIVE Project: Functional and clinical outcomes of telemedicine in patients with spinal cord injury. Arch Phys Med Rehabil 89: 2332-2341 (2008)
Vis C, Kleiboer A, Prior R, Bones E, Cavallo M, Anne Clark S, Dozeman E, Ebert D, Etzelmueller A, Favaretto G, Fullaondo Zabala A, Kolstrup N, Mancin S, Matthiessen K, Myrbak VN, Mol M, Jimenez JP, Power K, van Schaik A, Wright C, Zanalda E, Pederson CD, Smit J, Riper H, MasterMind Consortium. Internet Interventions 2015, DOI http://dx.doi.org/10.1016/j.invent.2015.10.002 (2015)